A Brief Overview

Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

Responsibilities

* Participate in project planning, recording, and evaluation of data.

* Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).

* Acquire technical, lab management, and grant writing skills.

* Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.

* Supervise junior lab members.

* Assist with other research projects as needed.

Education Qualifications

• Doctorate (required)

The Novel Therapeutics for Bleeding Disorder (NoT Bleeding) Program is an institutionally funded effort at the Children's Hospital of Philadelphia (CHOP) Research Institute to develop new, more effective treatments for patients with bleeding disorders and integrate novel therapies safely into clinical practice. Translational research projects are focused on the use of monoclonal antibodies, gene addition, and gene editing and will be conducted in the laboratories of Dr. Rodney Camire, Benjamin Samelson-Jones, and Lindsey George with extensive collaborations between the groups. Experimental approaches include recombinant protein production and purification, biochemical studies, mammalian and induced pluripotent stem cell culture, AAV vectors, and murine hemostatic models.

SPECIFIC LAB INFORMATION:

The Not Bleeding Frontier Program () will provide an ideal training environment for scientists interested in translational research. The George laboratory is part of the Division of Hematology at CHOP and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics () that includes a team of investigators committed to developing protein, cell, and gene therapy approaches to treat genetic disease, including hemophilia.

The Children's Hospital of Philadelphia and University of Pennsylvania offer a rich scientific environment for training in hemostasis and thrombosis. With over 30 laboratories dedicated to this space, a center dedicated to blood research, multiple NIH training grants, collaborative laboratories, cross campus meeting, and focus on mentorship and training, it is an ideal environment to start or expand your career in the blood sciences.

Dr. George's laboratory studies the molecular basis of coagulation and how disturbances in their function lead to disorders of bleeding and thrombosis. We are interested in translating basic molecular and biochemical insights to improve therapeutics for disorders of hemostasis, namely hemophilia. Specifically, we are interested in developing novel gene addition or gene editing approaches for hemophilia and understanding the mechanism of inhibitor formation in hemophilia.

A variety of enzymatic, biochemical, and molecular biology techniques are used in the laboratory in order to carry out our specific goals. For example, the following techniques are routinely performed in the laboratory: modern molecular methods (site-directed mutagenesis, cloning, etc.), tissue culture, protein purification, HPLC, FPLC, SDS-PAGE, ELISA, enzymatic kinetic assays, fluorescence spectroscopy, fluorescence anisotropy measurements, mouse modeling of hemostasis, designing AAV vectors etc. We aim to expand our gene editing work. Experience with gene editing technology, iPSC, and advanced molecular biology techniques is preferred.

Highly competitive salary and benefits are offered.

Curriculum vitae should be sent to:

Dr. Lindsey George, The Children's Hospital of Philadelphia, CTRB, Rm. 5016, Philadelphia, PA 19104. Email:

More info can be found at:

Postdoctoral fellows at The Children's Hospital of Philadelphia receive mentored training in a rich scientific and collaborative environment that includes the resources of the adjacent University of Pennsylvania. Visit for more information about The Children's Hospital of Philadelphia Research Institute and its research programs.