Waksman Institute, Rutgers, The State University of New Jersey seeks to hire a Postdoc Associate to conduct research on RNA polymerase structure and function and on small-molecule inhibitors of RNA polymerase. Uses tools of single-molecule biophysics (single-molecule fluorescence and/or single-molecule nanomanipulation), structural biology (cryo-EM), and/or biochemistry and molecular biology to define structures and structural transitions of transcription complexes and to identify and characterize small-molecule inhibitors of transcription. Prepares text, tables, and figures for patent applications publications. Presents results at scientific meetings.

Performs professional level experiments and research using various techniques. Carries out routine and non-routine work with review of work outputs by supervisor. Documents work performed and maintains a notebook and database. Communicates effectively with supervisor. Uses and helps maintain highly specialized equipment, in addition to maintaining and keeping the workplace and laboratory organized in a clean and safe manner in accordance with established procedures. Trains and leads research staff, postdoctoral associates, students, and technicians in laboratory related activities. Performs professional work requiring specialized knowledge and application and use of concepts, theories, terminology, and practices.

Requires a doctorate in biochemistry, molecular biology, or an allied field.
Effective spoken and written English required.

High level of compter literacy required.

Requires in-depth understanding and hands-on experience in preparation and analysis of proteins, nucelic acids, and complexes thereof.

Requires in-depth understanding and hands-on experience in molecular cloning, sequencing, and site-directed mutagenesis, and unnatural-amino-acid mutagenesis,.

Requires in-depth understanding and hands-on experience in fluorescence, including fluorescence resonance energy transfer and fluorescence anisotropy.

Experience in chromatography (including FPLC and preferably including HPLC) and electrophoresis required. Experience in work with chemical hazards and radiological hazards required. Experience in work with biological hazards (biosafety levels 1 and 2) preferred.

Average to above-average levels of mobility expected for laboratory environment.,

Average to above-average levels of upper-body strength expected for for lifting and working with bioreactors, large-volume culture flasks, Dewar flasks, cryo reservoirs, and other heavy items.