Senior Staff System Architecture Engineer
Pleasanton, CA 
Posted 15 days ago
Job Description

About the role:

10x Genomics is a rapidly growing company in the life sciences, whose core technology combines advances in instrumentation, chemistry, biochemistry, microfluidics, and computational biology. 10x Genomics is looking for a Senior Staff System Architecture Engineer to join its Instrumentation Engineering team supporting the design and development of our current and future platforms.

A competitive candidate must have deep knowledge and demonstrated hands-on experience in System and Electrical Engineering of automation and life sciences product development; analog and digital board design from conception to production; and electrical architecture design of instruments, which includes motion, fluid handling, sensor and pressure controls.

What you will be doing:

  • Provide hands-on leadership of individual projects from conception to production.
  • Define system and subsystem architectures, and approaches to meet project and program design goals.
  • Develop key relationships with internal design teams, as well as subcontractors, to plan comprehensive product strategies based on future technologies.
  • Collaborate with cross-functional team members (mechanical, optical, firmware, software, microfluidics, and quality) to solve complex, system-level designs and challenges.
  • Contribute to the assembly, bring-up, and troubleshooting of the different prototypes.
  • Ensure that the product meets or exceeds the requirements of both the customer and internal.
  • Work with a broader team to drive toward robust and cost-effective solutions.
  • Leverage deep understanding of signal integrity to ensure proper layout and grounding techniques that allow for the coexistence of high-speed digital signaling with high current, high slew rate, precision analog circuitry.
  • Act as a technical and market expert with engineering teams and customers to achieve product goals.
  • Actively contribute to low-level firmware and embedded software architecture.
  • Support compliance certifications, domestic and international.
  • Communicate project status across-functional organization and management levels.

To be successful, you will need:

  • Bachelor or Master's degree in Electrical Engineering or equivalent, with minimum 10 years of relevant experience.
  • Strong technical experience in developing and implementing complex system architecture and electrical designs with minimum to no supervision.
  • Demonstrated history in successfully defining and implementing complex electrical architecture to simultaneously manage illumination, communication, and video link across several sub-assemblies.
  • Solid understanding of overall system-level design approaches.
  • Deep knowledge of key interfaces/subsystems (e.g., microprocessors, memory, USB, Ethernet, i2c, CAN, Wi-Fi, and Bluetooth) and exceptional board bring up and debugging skills.
  • Knowledge of motion control, LED and laser drivers, camera imaging, and monitoring devices.
  • Experience with a variety of sensor technologies (e.g., thermal, optical, position, pressure, and flow).
  • Hands-on experience with PCB assembly and testing using various lab equipment, such as oscilloscopes, logic analyzers, power analyzers, spectrum analyzers, and network analyzers.
  • Practical knowledge of embedded FW/SW for microcontrollers.
  • Knowledge of product development cycles and its documentation.
  • Experience running designs through DfX reviews.
  • Experience designing/driving development and manufacturing test plans.
  • Solid knowledge of compliance standards, EMC, and safety certifications.
  • Experience with mitigating ESD, EMI, noise, and distortion to electrical signals in complex systems.
  • Excellent written and verbal communication skills.
  • Knowledge of FPGA macro architecture for data and control processing pipelines as well as FPGA sizing and selection.
  • Strong desire and capacity to work in a fast-paced development environment; you must be ready to produce high-quality work on short product deadlines.

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation,or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Bachelor's Degree
Required Experience
10+ years
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