Can you imagine yourself working in a high performing translational medicine department shepherding the next generation of medicines to address unmet medical need in patients across the globe?The Discovery Medicine (DM) department within the Clinical Pharmacology and Experimental Medicine (CPEM) unit in the Research organization at GSK is comprised of physicians and scientists striving to deliver these medicines.The DM Physicians and Scientists have deep scientific expertise in translational medicine and early clinical development and broad medical expertise across diverse therapeutic areas. They are recognized both within GSK and in the broader pharmaceutical and academic community as a leaders in Drug Discovery, Translational Medicine and Drug Development. Many are leading experts in their disease/therapeutic area of training.The DM Physician Director is responsible for rigorous assessment of clinical tractability and therapeutic potential to inform the most appropriate development strategy for new targets in discovery. In addition, the Director is accountable for strategic translational plan and the design of early clinical studies to provide confidence to invest in Phase 2 clinical proof of concept studies.You will have a thorough understanding of the assets you are working on, the biological mechanisms of action, and the relevant disease indications. Accountabilities will include provision of medical and scientific input and leadership to the Research Units' targets and assets. You will support target validation, development feasibility, and potential strategies for early clinical development of compounds prior to candidate selection. The leadership you provide will continue through development through accountability for the design and delivery of the early Clinical Development Plan (CDP), working with the Early Development Lead (EDL), project team and study teams, to deliver data that will support progression to full development of the medicine.The Director, Discovery Medicine will also provide clinical support/leadership for proof of mechanism studies (POM) for compounds in Development. You will be accountable for medical governance and regulatory reporting at the project level (and in support of the Clinical team) through clinical interpretation of data (clinical and non-clinical) that can impact patient safety and clinical efficacy.To succeed in the role, the successful candidate will also need to work closely with a broad, global, matrix team of project representatives and external collaborators.Location of the roleUpper Providence, Collegeville, PA
The responsibilities of the DM Physician Director include several key areas including but not limited to the following:
Strategy and Matrix leadership
Medical Governance and Study Safety
You will be highly experienced in drug development or translational medicine. You will be expected to work across multiple Discovery Medicine projects, demonstrating independent accountability for your own projects. You will set long term scientific strategy and be capable of executing this strategy based on your own expertise and that gained from your network.
You will play a leadership role in
- DO, MD, or equivalent physician degree +/- advanced degree (PhD preferred)
- Immunology/Allergy training and experience: fellowship/certification preferred
- In-depth experience in translational medicine and drug development (Research & Development)
- Track record in taking assets from lead optimisation to candidate selection
- Experience of setting and executing scientific strategy, whilst being mindful of overall company goals
- Experience in Clinical Trials including early clinical development (FTIH, phase 1)
- Understanding and knowledge of early development (drug metabolism, biomarkers, etc.) across different modalities of agents (small molecules, biologicals)
- Experience in working with relevant regulatory bodies and professionals in early stage discovery and development
- Excellent presentation, influencing and media skills for both internal and external audiences.
- Experience in networking with academic and research institution physicians and scientists
- Ability to lead and contribute to a global cross-functional team of senior leaders
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These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
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